Missouri Road Trips

Missouri is called the "Show-Me" State, and that's exactly what it does. Show your family a good time with a road trip through Missouri, where you'll find local eateries, breweries, award-winning barbeque and endless outdoor adventures. Rent a car from Enterprise and start your journey today!

Missouri Road Trips

Drive From Chicago to St. Louis

Looking to go from Chicago to St. Louis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to Chicago? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to Indianapolis? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to Kansas City? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to Little Rock? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to Milwaukee? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to Nashville? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to Pensacola? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Looking to go from St. Louis to the Ozarks? Driving may be your best option. Our neighborhood locations are open and ready to serve you with curbside pickup and modified cleaning procedures.

Find your perfect road trip destination in Missouri. Take a ride with Enterprise Rent-A-Car and start your journey today!

See All Road Trips

Looking for more road trip ideas? Check out our Road Trip Planner and choose your next journey!

Road Trip Ideas

Start A Reservation

Enjoy fast and easy car rental bookings from Enterprise Rent-A-Car at one of our 7,200 branches in cities, airports and neighborhoods near you.

Reserve a Rental Car

Missouri Road Trips